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Doses as high as 4,500 mg have been used in scientific studies, but participants took these amounts under controlled, safe conditions for a strictly defined period of time
miRNA expression values for murine liver tumors 24 are available at GEO accession code GSE44570
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They showed that the CDK9 inhibitor Z11 effectively suppressed tumor growth in osimertinib-resistant models, thereby capturing clinical resistance mechanisms
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