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It is controlled by carbon catabolite repressor (CCR), a regulatory system in most bacteria (92)

Results in the combination have been comparable to high efficacy therapies like Trizepatide

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The medicinal-chemistry programme that produced cagrilintide, described by Kruse and colleagues in the Journal of Medicinal Chemistry in 2021, addressed this by re-engineering the amylin backbone with structural elements borrowed from calcitonin (a related, non-aggregating peptide) and attaching a fatty-acid side chain that enables reversible binding to serum albumin [1]