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Clinical mechanisms include: Tyrosinase enzyme inhibition reducing active melanin synthesis Free radical neutralisation reducing oxidative triggers for pigmentation Glutathione peroxidase support protecting cellular membranes from oxidative degradation Hepatic detoxification enhancement supporting liver clearance of toxins that contribute to dull, uneven skin Anti-inflammatory action reducing chronic low-grade dermal inflammation that worsens pigmentation Collagen precursor support indirectly supporting skin firmness and elasticity through reduced oxidative collagen degradation IV Glutathione Treatment Protocol at Our Mumbai Clinic The specific IV formulation administered to each patient at our Andheri West clinic is determined following a pre-treatment medical consultation

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Opioid use may worsen gastric retention Higher prevalence of recent opioid use in the high RGC group Suggests an additive effect on gastric motility No difference in indication or duration of therapy Whether patients used GLP-1 RAs for diabetes or weight loss did not affect risk Duration of therapy was not a significant predictor Interpretation Withholding 7.5 days higher risk of retained gastric contents Fasting 21.3 hours strongest predictor of high RGC These thresholds optimize sensitivity and specificity for detecting risk

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doi: 10.3389/fnut.2024.1479186 328 HidayatKZhangLWeiHZhangWQinLOuYet al