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In addition to detecting phosphoregulation of proteins downstream of G s like filamin A 32 and GSK3A 33 , we also detected evidence of pathway-specific activity like AP2 by ARR 34 , AKAP5 by G s /G q 35 , ARHGEF11 by G i /G 13 36, 37 , AKAP13 by G s /G q /G 13 38 and trafficking related proteins like GBF1, RAB1B and -synuclein (Supplementary Fig