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GLP-1 and GLP-1RAs promote the expansion of -cell mass by stimulating -cell proliferation, inducing islet neogenesis, and inhibiting -cell apoptosis (Wajchenberg, 2007)
It impairs insulin sensitivity, increases cortisol production, and reduces the secretion of growth hormone, which plays a critical role in fat oxidation and muscle preservation during sleep
Although GLP-1s are generally safe for the liver, its important to check, especially before compounded meds Kidney function: to watch for stress on the kidneys, which can be exacerbated by GLP-1-induced dehydration and nausea, especially in older adults or those with preexisting conditions [1] Thyroid markers : to screen for an under-functioning thyroid gland, which can mimic or worsen weight gain
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