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Measurement of GLP-1
The effect of acylcarnitine on insulin sensitivity is also related to the saturation of acylcarnitine, with myotubes incubated with C16-carnitine exhibiting reduced insulin sensitization, whereas the accumulation of oleoylcarnitine (C18:1-carnitine) and linoleoylcarnitine (C18:2-carnitine) increases insulin sensitization [77]
Additionally, apart from IR being a new effective target for systemic PD treatment, studies on T2DM have found that ROS production and mitochondrial damage in muscle tissues of hyperglycemic mice can be normalized with antioxidant treatment and blood glucose control (56), suggesting that T2DM treatment strategies could provide new insights and strategies for future PD research and treatment
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