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L., Koob, G
For instance, SURPASS-1 demonstrated the effectiveness of its standalone therapy, with significant reductions in HbA1c levels and notable weight loss [43]
In other words, the mechanism makes microdosing biologically plausible, but reliable outcomes remain tied to dose levels that have been studied
Side Effect Mitigation: A low starting dose helps to prevent or lessen the severity of common gastrointestinal side effects
The trade-off is that daily injections require more discipline and create more opportunities to miss doses, which can reduce effectiveness
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