Research shows that when people stop taking GLP-1 drugs, they tend to regain weight and most of what comes back is fat, not muscle
But they contain different active ingredients, work through different mechanisms, and as the landmark 2025 SURMOUNT-5 trial revealed they do not produce equal results
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One wrong move, whether it is squirting water directly onto the lyophilized powder, shaking the vial to speed up dissolution, or choosing the wrong diluent, can degrade the peptide before you ever draw your first dose
Retatrutide is still in phase 3 trials, so its not on the market yet