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The most useful nuance for readers comparing headlines: REDEFINE 1's 20.4% number is the treatment-policy estimand (closer to intention-to-treat what happens regardless of whether participants stayed on treatment)
Research suggests the anabolic ceiling for most individuals occurs around 40-50 mcg/day (Philippou et al., 2007)
Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes: the DEPICT-1 52-week study
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