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-Syn interacts with Fe + and Fe + , promoting lipid peroxidation and ROS generation, which accelerate oxidative stress and ultimately drive ferroptotic neuronal loss (248)

The standard documented trial initiation dose is 0.3 mg once weekly, escalating over approximately 16 weeks toward higher investigational target doses, including the 2.4 mg/2.4 mg fixed-dose co-formulation regimen used in CagriSema studies [2]

Several factors influence which medication may be the better fit

Proven 20% MACE reduction in SELECT (obesity) and 26% in SUSTAIN 6 (T2D), while exenatide only achieved non-inferiority in EXSCEL

This differential represents substantial cost avoidance while maintaining appropriate access for patients with documented T2DM diagnoses who are prescribed these increasingly preferred therapies