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2013, and FDA's December 2024 review lists the same trial set

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FIGURE 3 3.2 ROS-induced damage to cellular biological macromolecules ROS possess strong oxidizing properties and can directly or indirectly attack intracellular biological macromolecules, disrupting cellular structure and function, thereby mediating cell apoptosis or abnormal proliferation and participating in the pathological process of skin diseases (Figure 4)

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