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Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease
(2025) 39:e70649
Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term
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These trials are of low quality, and as such, use in widespread clinical practice is premature
