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Prominin2 is a protein related to the regulation of lipid dynamics, which can promote the formation of ferritin-containing multivesicular bodies (MVB) and exosomes, transport iron out of cells, and inhibit ferroptosis
Further large-scale trials/studies are needed for longer durations to validate the use of these systemic agents for the treatment of melasma, thus, enriching our therapeutic armamentarium
Typically 250500mg daily
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The Sikiric research group at the University of Zagreb has published extensively on BPC-157s cytoprotective and wound-healing properties since the early 1990s, covering gastric mucosal protection, systemic healing, and neuromodulation
