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This past June, the biotech giant published phase 2 results for MariTide (maridebart cafraglutide), a long-acting GLP-1 drug designed to be injected once a month rather than once a week
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In the authors anecdotal experience, when further uptitration is not tolerated, but treatment effects are noted, maintaining the patient at the lower tolerated dose may be preferable to discontinuation
A patient who begins GLP-1 therapy often experiences significant fatigue, nausea, and reduced appetite in the early weeks
The expression of FDX1 and LIAS proteins were also significantly increased in the renal tissues in db/db mice, compared to db/m controls (216)
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