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The largest psychiatric safety meta-analysis to date found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall ( Pierret et al., JAMA Psychiatry, 2025 ), and a post-hoc analysis of the major semaglutide weight management trials found no differences in depression, suicidal ideation, or suicidal behavior compared to placebo ( Wadden et al., JAMA Internal Medicine, 2024 )
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The researchers are planning a randomized trial to test whether benefits extend beyond weight to cardiovascular and metabolic markers
Can I switch from PeterMD semaglutide to PeterMD tirzepatide
These symptoms are generally mild to moderate in severity and tend to diminish over time as physiologic adaptation occurs
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