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doi: 10.1017/S0007114516000696 50

Research suggests that women may respond more strongly than men to a long-acting GLP-1 agonist in reducing food cravings, especially the desire ("wanting") to eat for reward

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[7] [8] Prescription and administration: Once B12 deficiency is confirmed, GPs prescribe hydroxocobalamin injections according to standardised protocols: Standard loading regimen: 1mg intramuscularly three times weekly for two weeks Neurological involvement: 1mg intramuscularly on alternate days until no further improvement Maintenance therapy: 1mg every three months for life in pernicious anaemia or malabsorption conditions (or every two months if there was neurological involvement) Injections are typically administered by practice nurses at GP surgeries

This gradual approach, starting at 0.25 mg weekly, minimizes gastrointestinal side effects while allowing the body to adapt