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Metabolic analysis Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured with a 24-well XF Extracellular Flux Analyzer (Agilent Technologies) and Seahorse Wave Controller Software (Agilent Technologies), according to the manufacturers instructions

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a commercial product called PROFIN) in a single-center, double-blind, randomized, placebo-controlled study in 72 healthy women (4065 years of age) with moderate eye wrinkles who met the study criteria [45]