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Notably, mitochondrial Drp1S616P interacts with Rab7 at the MLCS to mediate PINK1-Parkin-dependent mitophagy in hepatocellular carcinoma cells (Che et al., 2022)

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Moreover, although the autophagy of mitochondria (mitophagy) may sequester iron in mitophagosomes to prevent iron from releasing into the cytoplasm in the early stages of iron overload, extensive mitophagy can conversely trigger Fe 2+ liberation, elevate cytosolic Fe 2+ levels, and amplify ferroptosis (Yu et al., 2022

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