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For pernicious anaemia : Lifelong replacement therapy is required, as the underlying absorption defect cannot be corrected
NICE and British Society for Haematology guidelines recommend: Initial treatment with hydroxocobalamin (the preferred form in the UK) via intramuscular injection For patients without neurological involvement: 1 mg IM three times a week for 2 weeks For patients with neurological involvement: 1 mg IM on alternate days until no further improvement Maintenance: 1 mg every 3 months for patients without neurological involvement
\Diagnostic Tool: Can be used to assess the pituitary gland's capacity to release growth hormone
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Fonseca VA et al
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