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In this regard, we note that RNAi-mediated reduction of epn-1 activity reduces the extent of the germline stem cell zone, consistent with a modest effect on DSL signaling to the germline [10], for which both LAG-2 and APX-1 serve redundantly as ligands [35]
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the Epac-dependent signal induces explicitly expression of Mn-SOD, GPx-1, and catalase in cardiomyocytes and hepatocytes, reducing ROS and protecting cells from oxidative stress (43)
117 Additionally, to improve patient compliance, it is crucial to extend the drugs half-life
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