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doi: 10.1038/nature11209 21 HettaHFRamadanYNAlharbiAAAlsharefSAlkindyTTAlkhamaliAet al
For context, the concentrations required to activate intracellular cascades such as PI3K/Akt, upregulate BDNF, or stimulate autophagy in neuronal tissue are derived from preclinical studies that used substantially higher relative exposures than those achievable in the human brain at therapeutic doses
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