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BB mainly contributed to sections Introduction, BloodBrain Barrier, BloodCerebrospinal Fluid Barrier, and Neurovascular Unit, and Selenium Transport to The Brain Selenoprotein P and Low Molecular Weight Selenium-Species. BM mainly contributed to sections Introduction, Selenium Transport to The Brain Selenoprotein P and Low Molecular Weight Selenium-Species, and Conclusion and Perspectives. All authors contributed to the editing and discussion and agreed to submit the manuscript in its current state