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For these reasons it is generally avoided when other effective options (optimized medication, percutaneous rhizotomy, or Gamma Knife) are available

Inhibition of the TRPM2 and TRPV1 channels through hypericum perforatum in sciatic nerve injury-induced rats demonstrates their key role in apoptosis and mitochondrial oxidative stress of sciatic nerve and dorsal root ganglion

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Semin Oncol