Activation of endosomal TLR7/8 during SARS-CoV-2 may increase the inflammatory response resulting in severe and potentially lethal immunopathological effects in COVID-19 patients as consequence of the simultaneous release of pro-inflammatory cytokines and chemokines
Negative controls received only vehicle, whereas positive (death) controls were added with 2 l of an 18% paraformaldehyde solution immediately before viability determination
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Natali, A., Nesti, L., Tric, D