The only other human study, from 2015, was abandoned by 2016 the researchers had cancelled submission of the results [15]
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Skin repair mechanisms and related signaling pathways are mediated by different genes, such as AQP3 (encoding a protein responsible for transporting water and glycerol, participating in the skin lipid metabolism, and regulating the differentiation and proliferation of keratinocytes in the wound-healing process), COL2A (encoding the main fibrous protein of skin ECM), FGF2 (encoding an angiogenic and mitogenic factor stimulating the cells proliferation and migration at the wound site), ITGB (encoding the main ECM adhesion transmembrane molecule), SEPTIN4 (encoding a GTP-binding protein involved in the morphogenesis and physiological functions of many cells, like skin cells), as well as FGF7, FGFR2, PPARD, and STAT3 8,9,10,11,12,13,14,15,16
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Limitations included the predominantly White and female participants, as well as normal baseline metabolic values, which may have attenuated the improvements