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Excluding the three big GLP-1 active ingredients from the 503B bulks list would, if finalized, cut off legal large-scale compounded production of those drugs even when the brand products are no longer in shortage

Gandra S, Mojica N, Klein EY, Ashok A, Nerurkar V, Kumari M, et al

It does this by activating a protein called the vascular endothelial growth factor which initiates the formation of new blood vessels

But the long-term safety is completely unproven , and there are plausible mechanisms by which things could go wrong (such as promoting tumor growth or causing unwanted tissue changes)

You might notice subtle positives such as improved concentration, better appetite, or more restful sleep, but responses vary