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S2CID 28548170
It is involved in many biological processes including detoxification of xenobiotics, removal of oxygen-reactive species, regulation of the redox state of cells and the oxidative state of important protein sulfhydryl groups, and regulation of immune function
The teams findings illuminate how mutations in SLC33A1 disrupt this glutathione transport pathway, offering a molecular explanation for neurodevelopmental disorders such as Huppke-Brindle Syndrome, characterized by severe intellectual disability and progressive neurodegeneration
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