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Our findings do not exclude a positive role for endosomal signaling or -arrestin-1 recruitment in acute responses to physiological GLP-1, but highlight how the kinetic context must be taken into account when exploiting noncanonical pathways during drug development
Semaglutide improves insulin sensitivity and has demonstrated cardiovascular benefits in people with type 2 diabetes
Its effects are dose-dependent and context-dependent
Which helps explain why things feel harder
B.PottegardA
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