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The present study showed that linezolid-induced liver damage was demonstrated by an increase in the marker enzymes alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)
Its varied potential mechanisms are thought to include interaction with inducible and/or endothelial nitric oxide-generating systems, by influencing serotonin, dopamine, GABA, and/or opioid metabolism, and/or by directly aiding blood flow, repair, regrowth, angiogenesis, and remodeling
It also interacts with pigment-related hormone receptors that contribute to its calming effect on the immune system
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