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Large quantities of oxidative stress could render the benefits of glutathione less relevant

Nutrients 12(9):2762 Thakur V, Pritchard MT, McMullen MR, Wang Q, Nagy LE (2006) Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF- production

Without this cross-linking, collagen fibers would be mechanically unstable, compromising the structural integrity of skin, tendons, and blood vessels