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The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation

The commercial effect on a premium-priced new drug placed on step two or three is quantifiable: a new entrant in a therapeutic class where it is subject to step therapy behind an established generic will capture roughly 30-50% of its potential prescriptions in the first year, according to market access modeling from IQVIAs Access & Channel Insight studies

The STEP and SURMOUNT trials both included lifestyle counselling alongside the medication