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Before approving a new drug, the FDA typically requires companies to conduct a type of study called a randomized controlled trial, in which study participants are allocated by chance to groups that either receive the drug, or are administered a placebo
Perforator veins cross through the deep muscle layer in the legs to connect the superficial veins to the deep venous system
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It has a more extensive research history including human clinical trials, though efficacy results were insufficient for continued pharmaceutical development
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