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Kovai, N., et al

This condition is clinically referred to as increased intestinal permeability, or "leaky gut." Once the intestinal barrier is compromised, the body faces a severe crisis known as metabolic endotoxemia

& Schwarz, F

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin