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-KG can also be exported to the cytosol to be carboxylated into citrate through isocitrate dehydrogenase 1 (IDH1) and further into acetyl-CoA for de novo fatty acid synthesis (Fendt et al., 2013)
(2022) 6:e437
High baseline oxidative stress or chronic inflammation may theoretically justify antioxidant support, but this remains individualized and requires provider interpretation
Renal failure and/or hepatic failure : Follow phenobarbital levels and re-dose accordingly
AntonioVFrancescaFGraziaBMFedericaGAnnaCGiovanniSet al
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