c tirzepatide niacinamide is the dual-action one. Instead of working on a single hormone, it targets two — GLP-1 and GIP — which is why it tends to have a stronger effect on appetite c-tirzepatide/niacinamide Tirzepatide / Niacinamide Injection

Any of those could explain the difference

PubMed Systematic reviewGLP-1 class evidence2025 Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition Supports body-composition, lean-mass, and metabolic-risk context

Patients with thyroid issues, kidney problems, asthma, or who are pregnant or breastfeeding

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Weight Loss : Many patients experience substantial weight loss while taking Semaglutide, which is beneficial for those struggling with obesity