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However, the absence of diarrhea does not mean the drug is not working
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Based on clinical trial data, tirzepatide produces superior weight loss results, but the better medication depends on individual factors beyond just numbers
The risk was small in absolute terms, just over two in 1,000 for semaglutide users versus one in 1,000 for non-users
However, the Glu 138 -Phe 143 sequence clearly has -helical propensity, which is in agreement with the recent crystal structure of the homologous glucagon receptor TM domain showing an extracellular -helical extension of TM1 20
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