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The findings in the present work contribute to understanding the metabolic and molecular mechanisms behind tamoxifen resistance in breast cancer

Longitudinal changes in body weight will be evaluated using generalized estimating equation models to assess treatment effects, time effects, and treatment-by-time interactions

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Additionally, we have identified eight new adverse events (AE) which include ketosis, euglycemic diabetic ketoacidosis, pancreatic cancer, sixth cranial nerve palsy, hyperglycemic hyperosmolar nonketotic syndrome, elevated glycated hemoglobin, positional dizziness, and belching