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This multi-receptor approach yields synergistic metabolic effects

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This process leads to the activation of the B-cell nuclear factor-B (NF-B) complex, which in turn promotes the transcription of cytokines and inflammatory genes (Crespo-Quiles and Femena, 2025)

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45 GIP could exert both anti-atherogenic and pro-atherogenic effects, which may depend on the types of endothelia studied (Figure 3)