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Given high pill burden and some adverse effects, the researchers proposed 75-100mg/kg/day as a reasonable dose for future trials evaluating mebendazole in various cancers
However, despite lower bioavailability, L-carnitine injections and other supplements provide a greater single absorbed dose than standard dietary dosages
The subsequent reduction in membrane-bound TREM2 impairs macrophage efferocytosis, sustains chronic inflammation, and contributes to the progression from simple steatosis to MASH (67)
The FDA is still looking into this issue
Presented for research literature review only Paulson DJ et al
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