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More Than Meets the Eye"
Engineering of gasdermin D-cleaving proteases Although the evolved X(GD_L) proteases displayed promising activity through profiling activity in the PACE architecture, they failed to yield measurable kinetic parameters or substrate cleavage in mammalian cells, likely due to insufficient catalytic activity (Fig
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1) Datopotamab deruxtecan Datopotamab deruxtecan (Dato-DXd) is an anti-TROP2 ADC linked to topoisomerase I inhibitor deruxtecan via a cleavable linker
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