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Resveratrol, a polyphenolic stilbene, displays concentration-dependent biphasic actions, at low doses it can weakly mimic estrogenic effects via ER activation, whereas at higher pharmacologic concentrations it acts as an ER antagonist, inhibits aromatase transcription, and disrupts co-activator recruitment to the ER complex, thereby exerting anti-proliferative and pro-apoptotic effects in ER-positive breast cancer cells (192)
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Therefore, the 2022 KDIGO guidelines recommend long-acting GLP-1 RAs with established cardiovascular (CV) benefits as the preferred second-line therapy for glycemic control and CV risk reduction in adults with type 2 diabetes with established cardiovascular disease (CVD) or a high CV risk profile
Under the pilot program, which will run from July 2026 to December 2027, Medicare will offer Wegovy, and two other GLP-1s, to qualified recipients for $50 a month
Glucuronidation and chemical disposition
