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Instead, it allows for targeted therapiessuch as BA sequestrants or novel FXR agoniststhat directly address the underlying pathophysiology of excessive colonic BA exposure, thereby offering the potential for more effective and mechanism-based relief of chronic secretory diarrhea
The TGA said it was also concerned about the unknown nature and safety of the ingredients used in manufacture
Studies suggest that up to 70% of people experience some form of GI symptoms, especially when starting treatment or increasing their dose
The SURPASS-2 trial demonstrated that tirzepatide was superior to semaglutide in reducing both HbA1c and body weight
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