the regulatory approval process of the FDA and comparable foreign regulatory authorities is lengthy, time-consuming and inherently unpredictable, and even if we complete the necessary clinical studies, we cannot predict when, or if, we will obtain regulatory approval or certification for any of our product candidates, and any such regulatory approval or certification may be for a more narrow indication than we seek
High fever affects multiple body systems: Increases fluid loss through sweating Accelerates metabolism and energy expenditure Can affect how medications are processed May indicate bacterial infection requiring antibiotics Gastrointestinal Illness Stomach bugs, food poisoning, or severe gastrointestinal flu present special challenges on GLP-1 therapy
Lipovac M, Bodner F, Imhof M, Chedraui P
A post hoc subgroup analysis assessing changes in BMI standard-deviation scores between participants with one or more gastrointestinal adverse events and those with none revealed that the effect of liraglutide in reducing BMI standard-deviation scores was independent of gastrointestinal adverse events (P = 0.82) (245)
W.la FleurS