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10.1016/j.intimp.2015.05.024 193 ZhaoJ.LiG.ZhangY.SuX.HangC

In the pivotal clinical trials that led to FDA approvalincluding the SUSTAIN trials for diabetes management and the STEP trials for weight managementmusculoskeletal symptoms including joint pain were reported, but at rates generally comparable to placebo groups

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77 In contrast, endothelial dysfunctionan early and independent predictor of cardiovascular eventscontributes to both macrovascular and microvascular pathology, playing a central role in the progression of diabetic CVD 78,79 (Fig