HEPES cGMP Manufactured Si-(C)4 Compounds 5 COLOR (Pt-Co) 25 RESIDUE

5 COLOR (Pt-Co) 25 RESIDUE AFTER IGNITION 0

00% PHOSPHATE (PO[@4@]) 5 ppm SULFATE (SO[@4@]) 0

00% MANGANESE (Mn) 0

70% ORGANIC IMPURITIES: THIOSALICYLIC ACID 0

SPECIFIC ROTATION [a][@D@] -28

HEPES cGMP Manufactured Si-(C)4 Compounds 5 COLOR (Pt-Co) 25 RESIDUETest Specification Min Max ASSAY (TITRATION) 99. 50% 99. 50% pH OF A 5% AQUEOUS SOLUTION 5. 4 5. 6 pKa @ 25 C 7. 35 7. 75 ABSORBANCE @ 260 nm (1. 0 M IN WATER) 0. 05 AU ABSORBANCE @ 280 nm (1. 0 M IN WATER) 0. 03 AU WATER (KF) 0. 50% HEAVY METALS (as Pb) 5 ppm INSOLUBLE MATTER 0. 10% TOTAL AEROBIC MICROBIAL COUNT 100 cfu g TOTAL YEAST AND MOLD COUNT 100 cfu g BACTERIAL ENDOTOXIN As reported