PE934020: Galα(1-3)lactose-β-PEG3-Azide label-new the lysosomal sulfatase deficient in

the lysosomal sulfatase deficient in Hunter syndrome (mucopolysaccharidosis type II)

The carbon-fluorine bond is stable

Alpha-2-Heremans-Schmid peptide (AHSG)

TF Epitope (Threonine)

4- triazol-3-one-d4

PE934020: Galα(1-3)lactose-β-PEG3-Azide label-new the lysosomal sulfatase deficient inN A N A A Gal1 3lactose ( Gal epitope) ligand equipped with an azide handle through a hydrophilic PEG3 spacer. The terminal azide couples to alkynes via copper catalyzed azide alkyne cycloaddition (CuAAC) or to DBCO and related strained alkynes via copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound presents a terminal Gal1 3 linkage corresponding to the Gal epitope (Gal1 3Gal1 4GlcNAc Gal1 3lactose), the target of