In a pediatric study, 1 (0.8%) Saxenda-treated patient died by suicide
Although preclinical studies have demonstrated promising outcomes, more randomized controlled trials are needed to assess whether GLP-1 can consistently improve cognitive function in patients with diabetes or those at risk of neurodegenerative conditions
however, it is associated with weight gain and deterioration of congestive heart failure
Eating large, high-fat meals may exacerbate feelings of fullness, nausea, or abdominal discomfort
Atherosclerosis progression, as a chronic inflammatory mechanism, is characterized by immune system dysregulation associated with increased pro-inflammatory cytokine production, including interleukin 6 (IL-6), tumor necrosis factor- (TNF-), and IL-1 (Vinciguerra et al., 2020