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We excluded 40 individuals who were already using insulin, 44 who started insulin therapy after discontinuing GLP-1 receptor agonists, and 70 with missing baseline or follow-up HbA1c values
Chatterjee SN stated that the permeability of the membrane has also been found to be increased in parallel with the lipid peroxidation indicating that the interior of the membrane undergoes alterations [17].Wolff SP et al stated that free radicals and oxidative stress may act as a common pathway to diabetes itself as well as to its later complications & found significantly higher lipid peroxide levels in diabetic than healthy individuals, matching our study results [18]
These pathways involve various intracellular messengers and enzymes, leading to changes in cellular activity
The Journal of Frailty & Aging, 8 , 154-159
Abstract Purpose of Review The aim of this review is to provide a comprehensive summary of current clinical evidence on the relationship between GLP-1 receptor agonists and pediatric obesity, to evaluate these findings from metabolic and therapeutic perspectives, and to offer potential directions for future research in the field
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