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Resveratrol hinders the PI3K/Akt/mTOR & Wnt/-catenin pathways, which result in cell cycle arrest and apoptosis, and activates SIRT1, a NAD+-dependent deacetylase, which impacts histone acetylation and p53 actions
LigPlot+: multiple ligandprotein interaction diagrams for drug discovery
Multiple sequence alignment analyses revealed that GSTO1-1 and GSTO2-2 contain a conserved catalytic cysteine residue and GSH binding sites, while other classes of GSTs have different amino acids in these positions, explaining why only GSTOs show DHAR activity 10,13
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