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Given that vagal afferents innervate the ENS, it is plausible that the ENS can relay local intestinal signaling mechanisms to the CNS

10.1094/PHYTO.1999.89.8.673 72 IshiharaT.SakuraiN.SekineK

Sermorelin's FDA Journey: Approved, Discontinued, and Compounded Sermorelin acetate (Geref) was FDA-approved in 1997 for pediatric GHD 1 and in 1990 for diagnostic use.26 The manufacturer discontinued Geref in 2008 due to "manufacturing difficulties," not safety or efficacy concerns.12 In 2013, the FDA confirmed it wasn't withdrawn for safety/effectiveness, allowing for potential generic approvals.12 Currently, Sermorelin is primarily available as a compounded medication 3, which is permitted but not individually FDA-approved like mass-produced drugs.22 5.2

This makes collagen synthesis a central research theme, although collagen-related cellular findings should not be translated into guaranteed skin tightening claims

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